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结节阴性阴茎状细胞癌中复发,转移和死亡的预测因素:一项回顾性多中心队列研究

Katie A O'Connell^1,2, Jacob L Thomas^3,4, Fadi Murad¹

¹Brigham & Women's/Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

Journal of the European Academy of Dermatology and Venereology : JEADV

|June 6, 2024

概括

历史的平衡炎和,以及差差分化,身体入侵和围神经入侵 (PNI),是阴茎状细胞癌 (PSCC) 结果的关键预后因素.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科
病理学病理学病理学

背景情况:

阴茎状细胞癌 (PSCC) 与显著的发病率和死亡率有关.
关于预后因素的数据有限,特别是在PSCC中转移的发展.

研究的目的:

确定临床结节阴性PSCC患者不良结果的独立预后因素.
评估结果包括局部复发 (LR),转移和疾病特异性死亡 (DSD).

主要方法:

一个32年的回顾性多中心队列研究.
包括265名经组织学诊断的PSCC患者.
开发基于患者和瘤特征的预测模型.

主要成果:

确定了五个独立的预后因素导致不良结果:平衡炎史,差异化不良,身体入侵,周围神经入侵 (PNI) 和先前的发病史.
差异化,PNI和身体入侵显著与转移风险增加有关.
对于具有PNI,身体入侵和差差分化的瘤,观察到5年累积转移发生率更高.

结论:

balanitis,phimosis,PNI,身体入侵和差异化的历史是PSCC中不良结果的独立风险因素.
由于差差分化和PNI目前被归类为T1b疾病,PSCC的预后阶段可能会得到改善.

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