左心房附属体伪血栓与心房动患者的中风史有关,这些患者接受心脏计算机断层扫描
Edward Nicol1,2,3, Nabeela Karim4, Tom Semple2
1Cardiology Department Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust London UK.
Journal of the American Heart Association
|June 6, 2024
概括
左心房附属物伪血栓 (LAAPT) 在非膜心房动 (NVAF) 中很常见,并显著增加中风风险. 心血管计算机断层扫描 (CCT) 的这一发现可能有助于分层化超出CHA2DS2-VASc得分的中风风险.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 左心房附属体 (LAA) 是非膜心房动 (NVAF) 中血栓的主要来源.
- 左心房附属物伪血栓 (LAAPT) 是初始心血管计算机断层扫描 (CCT) 扫描中的填充缺陷,其在NVAF患者的临床意义尚不清楚.
- 这项研究调查了在NVAF患者中LAAPT和中风史之间的关系.
研究的目的:
- 确定在CCT上发现的LAAPT与NVAF患者中风史之间的关联.
- 探索LAAPT是否可以在这个人群中作为中风的独立风险因素.
主要方法:
- 对213名连续NVAF患者进行CCT的队列进行LAAPT评估.
- 分析包括LA和LAA尺寸和形态与临床人口统计和中风史的相关性.
- 进行了多变量分析,以评估LAAPT与中风的独立关联,并根据CHA2DS2-VASc得分进行调整.
主要成果:
- 在213名NVAF患者中,LAAPT在27.7%的患者中被发现.
- 特定的LAA特征,包括较大的骨面积,体积增加和曲度较低,与LAAPT有关.
- 在CCT上,LAAPT与中风史独立相关 (OR,3.20),并且在对CHA2DS2-VASc得分进行调整后仍然显著.
结论:
- 在NVAF患者中,LAAPT是CCT的一个普遍发现.
- 拉普特显示出与中风患病率的强烈积极关联,独立于CHA2DS2-VASc得分.
- 通过CCT识别的LAAPT可能为NVAF患者的中风风险分层提供额外的价值.
相关概念视频
01:28Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...