血清25-基维生素D度与结石之间的关联:英国生物银行的队列研究
Chao Gao1,2, Meng Gao3, Yan Huang4,5
1Affiliated Changsha Hospital of Hunan Normal University, Changsha, 410008, China.
International urology and nephrology
|June 6, 2024
概括
较高的维生素D (25[OH]D) 水平通常不会增加结石的风险. 然而,在60岁以上的女性中,高25%的OH) D与较低的结石疾病发病率有关.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 营养科学 营养科学
背景情况:
- 维生素D缺乏是常见的,并与各种健康问题有关.
- 维生素D水平与结石疾病 (KSD) 之间的关系需要进一步调查.
研究的目的:
- 检查血清25-基维生素D[25(OH) D]水平与患结石病 (KSD) 的风险之间的关联.
主要方法:
- 利用了444,343名参与者的英国生物库数据.
- 在12.6年的随访期间,使用了Cox比例危险模型来评估基线血清25(OH) D和事件KSD之间的联系.
- 诊断KSD是基于医院记录.
主要成果:
- 总的来说,较高的血清25(OH) D水平与KSD风险的增加无关.
- 在60岁以上的女性中,较高的25(OH) D度 (≥50或≥75nmol/L) 与显著较低的KSD风险相关.
- 在老年女性中,这种保护性关联不依赖于血清水平.
结论:
- 当水平正常时,血清25(OH) D水平升高不会增加结石的风险.
- 研究结果表明,单独补充维生素D不太可能增加结石的发病率.
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