将抗菌素耐药性监测与杆菌病研究结合起来:一个相互关联的"一个健康"方法
Angus M O'Ferrall1, Janelisa Musaya2, J Russell Stothard1
1Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
概括
一个健康监测是了解抗菌素耐药性 (AMR) 和杆菌病传播的关键. 研究强调需要将AMR和杆菌病研究联系起来,以获得更好的公共卫生结果.
科学领域:
- 一个健康 一个健康
- 传染病流行病学 传染病流行病学
- 抗微生物耐药性 (AMR) 是一种
背景情况:
- 抗菌素耐药性 (AMR) 和杆菌病是全球重大卫生挑战,特别是在撒哈拉以南非洲.
- 人们越来越多地认识到菌体,微生物和AMR之间的相互作用,但了解得很少.
- 动物和环境在抗菌素耐药性和杆菌病的传播中起着至关重要的作用.
研究的目的:
- 在"一个健康"框架内审查AMR和杆菌病的相互联系.
- 为了检查共享的环境驱动因素和细菌和分裂体之间的殖民联系.
- 识别知识缺口,并为综合监测提出未来的研究方向.
主要方法:
- 关于AMR和杆菌病的现有文献的叙述性综述.
- 专注于Enterobacteriaceae中扩展谱β-乳糖酶 (ESBL) 介导的耐药性.
- 检查马拉维的新发现,并与其他地区进行比较分析.
主要成果:
- 越来越多的证据表明,分裂体,微生物和AMR之间存在显著的相互作用.
- 在共同传播中,环境因素和动物水库至关重要.
- 马拉维呈现了一个动态的景观,可以共同发展AMR和杆菌病.
结论:
- 需要在"一个健康"的方法下整合AMR和杆菌病研究.
- 进一步的研究应该调查杆菌病和淡水接触对肠道AMR殖民化的影响.
- 连接监测工作可以提高对这些共同流行病的理解和控制.
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