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患有异常性炎症性肌肉病的患者患有乳病的患病率,一个横截面研究
Rolando Áyax González-Leal1, Jiram Torres-Ruiz2, Nancy R Mejía-Domínguez3
1Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Clinical rheumatology
|June 6, 2024
概括
异形性炎症性肌肉病 (IIM) 患者表现出高患乳病 (CD) 自体的高患病率. 由于潜在的预后和治疗影响,建议在IIM患者中对CD进行查,特别是那些具有抗MDA5或抗Mi2抗体的人.
科学领域:
- 风湿病学和免疫学
- 胃肠病学 胃肠病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 乳病 (CD) 经常与其他自身免疫性疾病同时发生.
- 疾病和异常性炎症性肌肉病 (IIM) 之间的关系尚未得到充分证实.
- 了解这种关联可以为临床管理和预后提供信息.
研究的目的:
- 为了评估IIM患者的CD特征.
- 调查CD血清学,IIM临床表型和肌炎特异性/相关抗体 (MSA/MAA) 之间的联系.
主要方法:
- 99名成年IIM患者的横截面研究.
- 评估了血清MSA,MAA和CD自身抗体 (IgA抗tTG,IgA/IgG抗DGP) 的测试结果.
- 进行了十二指肠活检,以高度暗示CD血清学.
主要成果:
- 70.7%的IIM患者至少有一种CD相关的自身抗体.
- 两名患者 (2%) 通过活检确认了CD.
- 抗MDA5抗体与阳性抗tTG IgA和暗示CD血清学相关.
- 抗Mi2抗体与阳性抗DGP IgG相关,而抗NXP2则显示出相反的关联.
结论:
- IIM患者的血清学和确诊CD的患病率高于一般人群.
- 在IIM患者中,特别是那些具有抗MDA5和抗Mi2抗体的患者中,有必要对CD进行查.
- 需要进一步的研究来评估无质饮食对IIM患有CD标志物的患者的影响.
关键词:
结核病是什么? 结核病是什么?皮肤肌肉菌性炎 (dermatomyositis) 是一种疾病.异形性炎症性肌肉病变是一种异形性炎症性肌肉病变.MDA5 MDA5 MDA5 是一个简单的数字.这就是Mi2 Mi2 Mi2 Mi2在NXP2中,NXP2是NXP2.更多相关视频
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