严重的终身大麻使用和按性别的死亡率
1Department of Epidemiology and Public Health, Foch Hospital, Suresnes, France.
JAMA network open
|June 6, 2024
概括
大麻的大量使用与女性心血管疾病死亡率的增加有关,但对男性来说并不显著. 需要进一步的研究来了解大麻大麻.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
背景情况:
- 大麻使用与死亡率之间的关联仍然不清楚.
- 了解这些风险对于公共卫生指导至关重要.
研究的目的:
- 检查累积终身大麻使用与所有原因,心血管疾病 (CVD) 和癌症死亡率的性别分层关联.
- 调查英国生物库人口中的这些关联.
主要方法:
- 一项使用2006-2020年英国生物库数据的队列研究.
- 通过问卷,大麻使用被分类为严重,中度,低,或从未使用.
- 以性别分层的考克斯比例危险回归分析了死亡率结果,并调整了共变量.
主要成果:
- 在121,895名参与者中,大麻的大量使用显示出女性 (HR 1.49) 和男性 (HR 1.28) 的全因死亡率增加的趋势.
- 大麻的大量使用与女性心血管疾病死亡率的增加显著相关 (HR 2.67),特别是在目前的烟草使用者中 (HR 2.56).
- 大麻的大量使用也与女性吸烟者 (HR 3.52) 和男性吸烟者 (HR 2.44) 的癌症死亡率增加有关.
结论:
- 严重的终身大麻使用与女性心血管疾病死亡率之间存在积极的关联.
- 这些发现突出了大麻使用对死亡率的潜在性别特异性风险.
- 需要对一般人群进行进一步的纵向研究来证实这些关联.
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