对特征侵略和酒精使用的遗传风险预测了与酒精有关的侵略的独特方面
Kellyn M Spychala1, Ellen W Yeung1, Alex P Miller1
1Department of Psychological Sciences, University of Missouri.
概括
饮酒障碍的遗传风险和特征侵略性与与酒精有关的侵略性有关. 这些发现表明,在酒精影响下,对侵略性行为有独特的遗传影响.
科学领域:
- 行为遗传学行为遗传学
- 精神病学是一个精神病学.
- 成研究研究成研究
背景情况:
- 与酒精有关的攻击性是严重的公共卫生问题.
- 以前的研究表明,酒精使用与侵略性之间存在遗传联系.
- 与酒精相关的攻击性独特的遗传贡献仍未得到充分探索.
研究的目的:
- 调查特征攻击性,酒精使用和酒精使用障碍 (AUD) 和与酒精有关的攻击性多基因风险评分 (PRS) 之间的关联.
- 为了确定侵略性或酒精使用的遗传风险是否独特地影响与酒精有关的侵略性.
主要方法:
- 用全基因组关联研究总结统计数据创建特征侵略性,酒精消费和AUD的PRS.
- 在两个独立的样本中应用PRS来预测与酒精有关的攻击性:UCSF家庭酒精研究 (n=1,162) 和添加健康 (n=4,291).
主要成果:
- 在UCSF样本中发现了AUD PRS和终身与酒精有关的攻击性之间的显著关联.
- 攻击性特征PRS与特定的攻击性行为 (身体斗争,打人) 和UCSF样本中与酒精有关的攻击性综合得分有关.
- 在添加健康样本中没有发现任何显著的关联,并且观察到有限的性别特异性遗传效应.
结论:
- 初步证据表明,与酒精有关的攻击性存在独特的遗传影响.
- 这些遗传关联可能因与酒精有关的攻击性事件的类型和频率而异.
- 需要进一步的研究来阐明与酒精有关的侵略的复杂遗传结构.
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