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在高甲状腺症患者和T3治疗小鼠中降低了血清CLCF1水平

Xuan Zhou^1,2, Yanan Zhang^1,2, Youwen Yuan^1,2

¹Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.

The Journal of endocrinology

|June 6, 2024

概括

甲状腺激素 (TH) 可能会降低心肌类细胞因子1 (CLCF1) 的水平,从而影响热生成. 这项研究发现甲状腺功能高患者的CLCF1降低,小鼠脂肪组织中的CLCF1表达减少.

科学领域:

内分泌学在内分泌学.
代谢过程中的代谢.
分子生物学分子生物学

背景情况:

甲状腺功能障碍症表现出体重减轻和出汗等症状,这些症状是由影响热生成的甲状腺激素 (TH) 驱动的.
心脏类型细胞因子1 (CLCF1) 与发热和感冒引起的出汗综合征有关.
在调节热生成过程中TH和CLCF1之间的相互作用仍然在很大程度上未被描述.

研究的目的:

研究甲状腺激素对人类循环中的CLCF1水平的影响.
探索甲状腺激素如何调节CLCF1表达在小鼠模型中的能量代谢调节.

主要方法:

人类研究比较甲状腺功能过高患者和健康对照者的血清CLCF1水平.
用T3治疗的小鼠模型 (C57BL/6) 用于分析棕色脂肪组织 (BAT) 和 inguinal 白色脂肪组织 (iWAT) 中的CLCF1表达.

主要成果:

与健康人群相比,甲状腺功能高的患者表现出明显较低的血清CLCF1水平.
血清中CLCF1水平与甲状腺功能障碍独立相关.
在小鼠中,T3治疗导致了BAT和iWAT中CLCF1表达的减少.

结论:

甲状腺激素影响人类循环中的CLCF1水平.
TH可能会调节脂肪组织内CLCF1的表达,这表明它在能量代谢调节中的作用.

关键词:

类似于细胞因子1的心脏增生素因子1 甲状腺功能过强症甲状腺功能过强症热生成是一种热生成.甲状腺激素是甲状腺激素的一种.

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