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固体分散系统用于增强溶解水溶性较差的坎德沙坦西莱克塞特:体外评估和模拟的药理动力学研究

Israa Saad Mustafa Ali1, Uday Aziz Sajad1,2, Bazigha K Abdul Rasool3

  • 1Pharmaceutics Department, College of Pharmacy, University of Basrah, Basrah, Iraq.

PloS one
|June 6, 2024
PubMed
概括

这项研究开发了固体分散系统 (SDSs),以增强candesartan cilexetil (CC) 的溶解性和溶解性. 优化的SDS显著改善了CCCC的性能.

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
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