靠近管管功能障碍作为住院COVID-19患者AKI的预测因素
Amit Bari1, Muhammad Rafiqul Alam2, Sumona Islam3
1Department of Nephrology, Kidney Foundation Hospital and Research Institute, Dhaka, Bangladesh.
PloS one
|June 6, 2024
概括
靠近管管功能障碍 (PTD) 在COVID-19患者中很常见,并预测严重的结果. 早期发现PTD可以帮助识别患有急性损伤 (AKI) 和其他并发症风险较高的患者.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- 脏是COVID-19的早期目标,原因是近接管中的高度的 ангиотензин转化酶受体.
- 靠近管管功能障碍 (PTD) 可能作为急性损伤 (AKI) 和COVID-19患者疾病严重程度的早期指标.
研究的目的:
- 在COVID-19患者入院时调查近端管管功能障碍 (PTD) 的流行情况.
- 评估PTD与急性损伤 (AKI) 的发展,疾病严重程度和患者结局之间的关联.
主要方法:
- 这是一项前性观察性研究,涉及87名没有先前存在脏疾病的COVID-19患者.
- 在入院时对六种PTD标志物的查:高尿素,正常血糖糖,蛋白,脏酸盐泄漏,泄漏和泄漏.
- 通过前四个标志物中的至少两个的存在来定义PTD;在整个住院期间进行随访.
主要成果:
- 52.9%的患者在入院时表现出PTD,泄漏和蛋白尿是最常见的标志物.
- 患有PTD的患者患有AKI的几率明显更高 (ORs从17.5到25.5不等),需要ICU转移 (OR=9.4),机械呼吸 (OR=10.1),并经历死亡 (OR=10.3).
- PTD组的平均住院时间更长,32.6%在随访期间实现了完全的PTD康复.
结论:
- 靠近管管功能障碍 (PTD) 在COVID-19患者中在疾病过程的早期非常普遍.
- PTD是AKI,ICU入院,机械通风和COVID-19死亡率的重要预测因素.
- 早期识别PTD可能有助于对COVID-19患者的风险分层和管理.
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