生物类药物引入后生物价格的降低:57个国家和地区的分析,2012-19年
Hui-Han Chen1, Tatenda Yemeke1, Sachiko Ozawa1,2
1Division of Practice Advancement and Clinical Education, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, United States of America.
PloS one
|June 6, 2024
概括
生物仿制药的引入使全球和美国的生物药物价格大幅下降. 增加生物仿制药的使用是控制与生物制药相关的医疗保健成本上升的关键.
科学领域:
- 卫生经济学 卫生经济学
- 制药政策 制药政策
- 生物技术是生物技术.
背景情况:
- 生物疗法提供了显著的临床益处,但与高成本有关.
- 生物类似药的出现为减少医疗保健支出提供了机会.
- 了解生物类药物进入市场对原始生物价格的实际影响,对于政策制定至关重要.
研究的目的:
- 评估生物类药物进入市场对八种关键生物产品的原厂价格的影响.
- 分析全球和美国57个国家和地区的定价变化.
主要方法:
- 使用IQVIA MIDAS®年度销售数据,采用了中断时间序列设计.
- 分析涵盖了2012年1月1日至2019年12月31日期间的八种生物产品.
- 评估了生物类似药物进入后的即时和长期定价影响.
主要成果:
- 生物类似药的进入导致trastuzumab (438美元),infliximab (112美元) 和bevacizumab (110美元) 的每剂平均价格立即降低.
- 观察到,阿达利穆马布 (49美元),菲尔格拉斯蒂姆 (290美元),因弗利西穆马布 (21美元) 和特拉斯图祖马布 (189美元) 的每年价格持续下降.
- 在美国,filgrastim,pegfilgrastim和infliximab的价格每年分别下降了955美元,753美元和104美元.
结论:
- 生物类药物在全球范围内和美国内明显降低了生物产品的价格.
- 调查结果强调了生物类似药物利用的经济优势及其在管理医疗保健成本方面的作用.
- 促进生物类似药的可用性政策对于减轻由生物使用驱动的不断升级的医疗支出至关重要.
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