基于共识的指导方针,用于海湾合作委员会国家急性髓性白血病管理:解决未满足的区域需求和不断变化的AML景观
Murtadha K Al-Khabori1, Ahmad Alhuraiji2, Arif R Alam3
1Hematology and Bone Marrow Transplantation Department, Sultan Qaboos University, Muscat, Oman.
JCO global oncology
|June 6, 2024
概括
这项研究为海湾合作委员会 (GCC) 国家的急性髓性白血病 (AML) 管理制定了特定区域的指导方针,在诊断和治疗策略上达成了高度共识,以获得更好的患者结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床实践指南 临床实践指南
背景情况:
- 急性髓性白血病 (AML) 是一种复杂的血液癌症,患者需求多样化.
- 根据区域特点调整AML管理,可以改善患者的护理和结果.
- 海湾合作委员会 (GCC) 各国需要针对AML治疗的本地化建议.
研究的目的:
- 为AML管理制定特定区域的基于共识的建议.
- 为解决海湾合作委员会国家在AML护理方面的未满足需求.
- 为该地区提供个性化AML治疗的框架.
主要方法:
- 一个经过修改的两轮德尔菲流程,涉及来自科威特,阿曼,卡塔尔和阿联 (KOQU) 的十名反洗钱专家.
- 确定区域未得到满足的需求和核心变量.
- 根据国际准则和专家反,对声明进行投票和修订.
主要成果:
- 在AML管理策略方面达到了超过97.8%的共识.
- 同意使用国际风险分层来进行个性化的AML治疗.
- 确定了AML的诊断标准 (≥10%的爆发与复发性遗传异常).
- 建议针对复发性/耐药性AML的特定疗法,包括venetoclax-hypomethylating剂和向疗法.
- 由于细胞遗传学和遗传异常,在治疗老年AML患者方面存在公认的挑战,需要量身定制的方法.
- 强调基于当地抵抗模式的支持性护理.
结论:
- 在海湾合作委员会KOQU国家为AML管理制定了基于证据的区域具体建议.
- 建立了一个共识框架,以指导该地区的AML临床决策.
- 旨在通过标准化,但个性化的AML护理来提高患者的治疗结果.
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