急性病毒性支气管炎的表型是对葡萄糖皮质激素和支气管扩展剂治疗的反应
Andressa Roberta Paschoarelli Chacorowski1, Vanessa de Oliveira Lima1, Eniuce Menezes1
1Universidade Estadual de Maringá, Maringá, PR, Brazil.
Clinics (Sao Paulo, Brazil)
|June 6, 2024
概括
患有急性病毒性支气管炎 (AVB) 的婴儿在接受葡萄糖皮质类药物和支气管扩展剂治疗时,并没有减少具有亚型表型的住院时间. 在没有亚托皮的婴儿中使用抗生素与更长的住院时间有关.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 过敏和免疫学 过敏和免疫学
背景情况:
- 急性病毒性支气管炎 (AVB) 是婴儿常见的呼吸道感染.
- 目前对AVB的治疗指南通常包括支气管扩展剂和葡萄糖皮质激素,尽管它们的有效性仍有争议.
- 形表型在AVB结局中的作用需要进一步研究.
研究的目的:
- 为了确定是否亚托皮表型影响住院时间或氧气治疗持续时间的婴儿与AVB治疗葡萄糖皮质体和支气管扩展剂.
- 分析抗生素使用对AVB的婴儿住院时间的影响.
- 评估AVB的药物处方的频率.
主要方法:
- 一项回顾性流行病学研究分析了2012年至2019年期间住院患有AVB的58名婴儿的医疗记录.
- 接受葡萄糖皮质类药物和支气管扩展剂的婴儿根据亚托皮表型的存在或不存在进行了比较.
- 住院时间和氧气治疗持续时间是主要结果指标. 还分析了抗生素的使用情况.
主要成果:
- 100%的婴儿接受了支气管扩展剂,98.3%的婴儿接受了葡萄糖皮质醇.
- 在接受支气管扩展剂和葡萄糖皮质类药物治疗的婴儿中,阿托皮性表型的存在并没有显著改变住院或氧气治疗的持续时间.
- 接受抗生素的没有家族病史的婴儿在医院停留时间明显长 (p = 0.01).
结论:
- 在服用葡萄糖皮质类药物和支气管扩展剂时,阿托皮性表型似乎不会改变AVB的治疗结果.
- 该研究强调了与AVB的婴儿使用抗生素相关的长时间住院的令人担忧的趋势,特别是在没有明显的细菌共感染的情况下.
- 调查结果强调需要遵守既定协议,并加强AVB诊断和管理的专业培训,以优化患者护理和资源利用.
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