癌症与精神分裂症,严重抑郁症和双相情感障碍的关联:孟德尔的随机化研究
Xinyue Han1, Xiangying Lin2, Guanhong Li2
1Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Yiwu Traditional Chinese Medicine Hospital, Jinhua, Zhejiang 322000,China.
Journal of psychosomatic research
|June 6, 2024
概括
精神分裂症和严重抑郁症可能会增加患甲状腺癌的风险. 这项研究调查了主要精神障碍和各种癌症之间的因果关系,发现了与甲状腺癌的潜在关联.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 在瘤学瘤学.
背景情况:
- 精神疾病如精神分裂症,双相情感障碍和严重抑郁症被怀疑与某些癌症有关.
- 这些心理健康状况与癌症风险之间的确切因果关系尚未得到充分确立.
研究的目的:
- 调查精神分裂症,双相情感障碍,严重抑郁症和患常见癌症的风险之间的潜在因果关系.
- 为了澄清主要精神疾病和癌症发病率之间的关系的大小.
主要方法:
- 使用公开可用的全基因组关联研究 (GWAS) 数据进行了两样本的门德尔随机化 (MR) 分析.
- 对精神分裂症,双相情感障碍和抑郁症的遗传关联估计来源于精神病基因组学联盟.
- 与癌症相关的遗传数据来自大型联盟,包括英国生物银行,MRC-IEU和GliomaScan.
主要成果:
- 暗示性证据表明,基因预测的精神分裂症与甲状腺癌风险增加之间存在关联 (OR = 1.543,P = 0.039).
- 在基因预测的大型抑郁症和甲状腺癌风险增加之间发现了显著的关联 (OR = 3.573,P = 0.039).
- 对于精神分裂症,严重抑郁症或双相情感障碍,没有发现对其他研究癌症风险的因果关系.
结论:
- 研究结果表明,精神分裂症和甲状腺癌的发展之间存在潜在的关联.
- 重度抑郁症也与患上甲状腺癌的风险增加有关.
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