椎间盘的细菌鉴定:一个前性队列研究.
Nelson Astur1, Delio Eulalio Martins1, Michel Kanas1
1Department of Orthopaedics and Traumatology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
概括
昆虫细菌 (C. acnes) 感染不是腰椎间盘或微分隔切除术后的莫迪克变化的一个重要因素. 磁盘中的细菌存在率很低,与临床结果无关.
科学领域:
- 脊柱外科手术 脊柱外科手术
- 传染性疾病传染性疾病.
- 放射学 放射学是一门学科.
背景情况:
- 脊椎间盘培养中的Cutibacterium acnes (C. acnes) 存在表明它在炎症状况中起作用,导致Modic在MRI上的变化.
- 调查C. acnes的流行率对于了解其对脊柱健康的潜在影响至关重要.
研究的目的:
- 为了确定腰椎间盘的样本中C. acnes的流行率.
- 为了确定预后因素和莫迪克变化与感染之间的关系,在微小隔膜切除术后一年.
主要方法:
- 一项前性队列研究,涉及112名接受腰部微分隔切除术的患者.
- 盘,肌肉和带样本被培养;一个子集经历了下一代测序 (NGS).
- 临床结果,Modic变化和潜在的混因素在手术前和后被评估.
主要成果:
- 培养结果显示,盘子 (6.3%) 和带 (2.7%) 中细菌的存在很低,在2个盘子样本中发现了C. acnes.
- 在手术后一年,感染和非感染患者之间没有观察到Modic变化或临床结果 (疼痛,功能) 的显著差异.
- 在NGS分析中,没有在任何样本中检测到C. acnes.
结论:
- 在椎间板中感染性细菌的存在是不常见的 (<2%),并且通过磁盘微生物组分析没有检测到C. acnes.
- 在微隔膜切除术后,积极的组织感染和临床预后因素之间没有发现显著的关联.
- 这项研究表明,C. acnes不太可能是这种患者群体中Modic变化或不良结果的主要驱动因素.
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