全球间接治疗对比指南和最佳实践的有针对性的审查
Shiro Tanaka1, Ataru Igarashi2, Raf De Moor3
1Faculty of medicine, Kyoto University, Kyoto, Japan.
概括
间接治疗比较 (ITC) 提供了有价值的临床有效性数据,当头对头试验是不可用的. 准则越来越倾向于先进的ITC技术,其适用性取决于数据和证据的质量.
科学领域:
- 卫生经济学 卫生经济学
- 相对有效性研究研究比较
- 证据综合 证据综合
背景情况:
- 在缺乏直接比较数据的情况下,间接治疗比较 (ITC) 对医疗保健决策至关重要.
- 信息通信公司的治理和标准化报告对于最大限度地减少偏见和确保科学严谨性至关重要.
研究的目的:
- 确定关键的间接治疗比较 (ITC) 技术,用于客观和合理的分析.
- 评估ITC作为医疗保健干预措施的比较证据的适用性.
主要方法:
- 通过对Ovid MEDLINE (2010-2023) 的全面文献搜索以及对国际机构网站的手动搜索,确定了ITC的指导方针.
- 来自10个全球权威机构的68条指导方针被审查为方法和报告建议.
主要成果:
- 大多数指导方针将缺乏直接比较研究作为使用ITC的主要原因.
- 在大多数司法管辖区,以人口调整或定的ITC方法比天真的比较更受青.
- 对ITC的报告建议显示,尽管司法管辖区存在差异,但有一些共同点.
结论:
- 间接治疗比较 (ITC) 为临床有效性提供了至关重要的见解,特别是当对比试验具有挑战性时.
- 特定ITC方法的适当性和接受性取决于数据来源,可用的证据,以及益处或不确定性的程度.
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