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来自Isodon amethystoides的阿比坦二甲和它们的生物活动

Lang Zhou¹, Chen-Liang Zhao², Chuan-Yan Xu³

¹College of Pharmacy, Guizhou University of Traditional Chinese Medicine, No. 4 Dongqing South Road, Guiyang, Guizhou, 550002, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University / Natural Products Research Center of Guizhou Province, Guizhou, 550014, PR China.

|June 6, 2024

概括

从Isodon amethystoides中发现了七种新的阿比坦二特类物质. 这些化合物表现出细胞毒性,抗菌性和禽流感病毒抑制活性,而化合物4显示出显著的抗病毒作用.

科学领域:

自然产品化学自然产品化学
有机化学有机化学
药理学药理学是指药理学的学科.

背景情况:

伊索登美西斯托伊德 (Isodon amethystoides) 是生物活性天然产品的植物来源.
阿比二烯酸体代表了一类具有多样化生物活性的化合物.

研究的目的:

从Isodon amethystoides中分离和表征新的阿比二类物质.
评估分离化合物的细胞毒性,抗菌和抗病毒活性.

主要方法:

使用光谱方法 (2D NMR) 和X射线晶体学阐明结构.
对SMMC-7721癌细胞系的细胞毒性活性评估.
对抗Streptococcus sobrinus的抗菌活性的评估.
对禽流感病毒 (AIV) 抗病毒活性进行测试.

主要成果:

七种新的阿比二类化合物,阿比甲基A-G (1-7),被分离和结构特征.
化合物5在40μM时对SMMC-7721细胞表现出42.9%的细胞毒性.
化合物3和4对Streptococcus sobrinus表现出抗菌活性 (分别抑制了55.3%和63.2%).
化合物4显示出针对AIV的显著抗病毒活性,在25μM时抑制68.4%.

结论:

这项研究成功地鉴定和表征了来自Isodon amethystoides的七种新的阿比坦二特类物质.
隔离的化合物具有有前途的细胞毒性,抗菌性和抗病毒性质,特别是4化合物对抗AIV.

关键词:

亚比坦二次化物是什么?抗艾滋病毒活动.具有抗菌活性,具有抗菌活性.细胞毒性细胞毒性伊索登甲化物 (本瑟姆) H. 哈拉哈拉拉米叶科 (Lamiaceae) 是一个植物.

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