一个双响应的氧化/β-拉帕联合交付平台,用于氧化还原失衡增强的瘤治疗
Hui-Zhen Yang1, Jia-Jia Chen1, Lan Zhang1
1Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China.
概括
这项研究引入了LSNO,双响应性脂质纳米粒子,用于同时输送氧化 (NO) 和β-Lapachone (Lap). 这种联合治疗有效地通过诱导氧化应激和破坏癌细胞来抑制瘤生长.
科学领域:
- 纳米医学是一种纳米医学.
- 癌症治疗 癌症治疗
- 氧化压力是一种氧化压力.
背景情况:
- 氧化 (NO) 和β-拉帕 (Lap) 组合疗法通过诱导氧化应激,在癌症治疗方面表现有前途.
- 开发有效的配送系统,共同配送治疗药物对于提高治疗疗效至关重要.
研究的目的:
- 构建双响应性脂质纳米颗粒 (LSNO) 用于氧化物 (NO) 和β-拉帕 (Lap) 的联合输送.
- 研究LSNO介导的NO/Lap组合疗法对瘤的治疗疗效和潜在机制.
主要方法:
- 使用协调脂质 (DSNO(Zn),拉普和辅助脂质 (DOPE,DSPE-PEG2000) 合成了LSNO纳米颗粒.
- 使用光测试来确认光触发的NO释放和自我报告能力.
- 进行了体外抗瘤测定和机制研究,以评估细胞抑制,细胞亡,ROS产生和DNA/线粒体损伤.
主要成果:
- 在高度的谷氨 (GSH) 下,LSNO证明了光触发的NO释放和药物释放.
- 与单个治疗相比,通过LSNO的联合NO/Lap治疗显著抑制了瘤细胞的生长和诱导的亡.
- 该疗法通过增加活性氧物种 (ROS) 和过氧酸离子 (ONOO-),诱导氧化应激,破坏细胞内氧化还原平衡,损伤DNA,并导致线粒体功能障碍.
结论:
- 在瘤治疗中,LSNO作为NO和Lap联合交付的有前途的多功能平台.
- 联合疗法通过多种机制有效向癌细胞,包括氧化应激诱导和直接细胞损伤.
- LSNO有可能推进新的癌症治疗策略.
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