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单细胞分析揭示了肝脏内胆管癌中缺氧诱导的免疫抑制微环境

Yuan Liang1, Qingfa Bu2, Wenhua You3

  • 1School of Biological Science & Medical Engineering, Southeast University, Nanjing, China; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.

Biochimica et biophysica acta. Molecular basis of disease
|June 6, 2024
PubMed
概括

肝内胆管癌 (iCCA) 中的缺氧通过抑制免疫细胞促进瘤生长. 向前体耗尽的CD8+ T细胞提供了针对iCCA的潜在免疫疗法策略.

关键词:
氧气过低是因为缺氧.在肝脏内发生的胆管癌,胆管癌.前体已经耗尽的CD8T细胞.与瘤相关的巨细胞.这就是scRNA-seqq.

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