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来自Zanthoxylum schinifolium的骨中的新胺

Jia-Xin Xu¹, Li-Wu Lin², Min He²

¹School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

|June 6, 2024

概括

绿色的华 (Zanthoxylum schinifolium) 周骨产生了27种基胺,包括新型化合物. 一些孤立的胺酸对皮质激素诱导的细胞损伤产生了微弱的保护作用.

科学领域:

自然产品化学自然产品化学
药理学是指药理学,即药理学是指药理学.
药用化学医学化学

背景情况:

桑托克西 (Zanthoxylum schinifolium Sieb.) 是一种植物,它可以生长长长久. 朱子,被称为"绿色华",在中国传统民间医学和美食中被广泛使用.
基胺是Zanthoxylum物种中发现的一类重要化合物,以其多样化的生物活动而闻名.

研究的目的:

从绿色花中分离和表征基胺.
评估隔离化合物的神经保护潜力,以防止皮质类固醇诱导的PC12细胞损伤.

主要方法:

使用色谱技术分离化合物.
通过广泛的光谱分析 (1D,2D NMR,HRESIMS,UV) 阐明结构.
使用PC12细胞模型进行神经保护活性体外评估.

主要成果:

他们分离了27种胺基,包括一种罕见的二胺基 (1),一种含的胺基 (5),6种新的类型 (2-4,6-8) 和19种已知的化合物 (9-27).
化合物5,18,21和22在PC12细胞中表现出对皮质激素诱导的损伤具有较弱的保护活性.

结论:

该研究成功地从绿色花中确定了多种类型的胺,扩大了这种植物已知的化学特征.
这些发现表明,Zanthoxylum schinifolium中的某些胺酸具有潜在的神经保护性,需要进一步调查.

关键词:

基胺是一种基胺.神经保护性活动神经保护性活动黄叶植物 (Rutaceae) 是一个植物.桑托克西 (Zanthoxylum schinifolium) 是一种有机植物.

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