氧化和肠道微生物群调节:骨癌疼痛管理的潜在治疗策略
Zhen Liu1, Haishao Chen1, Xing Ning1
1Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, China; Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine, Nanning, China; Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction, Nanning, China.
The journal of pain
|June 6, 2024
概括
骨癌疼痛 (BCP) 与肠道微生物群变化有关. 恢复肠道微生物群或补充黄油酸可以缓解BCP并改善血脑屏障的完整性. 氧马还显示出治疗潜力.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性疼痛,包括骨癌疼痛 (BCP),与肠道微生物组成的改变有关.
- 肠道微生物群在BCP中的特定作用及其对血脑屏障 (BBB) 的影响仍然不完全理解.
研究的目的:
- 调查肠道微生物群在BCP中的作用.
- 评估氧马 (OMT) 对肠道微生物群和BCP的治疗作用.
- 评估微生物群调节和黄油酸补充对BCP中的疼痛行为和BBB完整性的影响.
主要方法:
- 开发了一个BCP小鼠模型来分析肠道微生物群,黄油酸水平 (血清和大脑),以及BBB透性.
- 采用微生物群移植,Clostridium butyricum和酸盐 (NaB) 补充剂来恢复肠道微生物群并评估对疼痛和BBB的影响.
- 评估了氧氨酸 (OMT) 对肠道微生物群,PPARγ/COX-2信号传递,BBB完整性和疼痛行为的影响.
主要成果:
- BCP显著改变了肠道微生物群的组成,并降低了血清和脑组织中的黄油酸水平.
- 在BCP小鼠中,BBB的透性增加;微生物群移植和酸盐补充剂 (C. butyricum或NaB) 改善了疼痛行为并改善了BBB完整性.
- 在BCP模型中,OMT调节了肠道微生物群,调节了PPARγ/COX-2信号,改善了疼痛行为和BBB完整性.
结论:
- 肠道微生物群组成和黄油酸水平在BCP中受到显著影响.
- 调节肠道微生物群和黄油酸水平可以缓解BCP并增强BBB完整性.
- 氧马 (OMT) 通过影响肠道微生物群和调节关键信号通路,显示出作为BCP治疗剂的潜力.
更多相关视频
相关概念视频
01:15Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
159
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
159
01:25Analgesia and Pain Management
579
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
579
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
194
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
194