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在amnestic轻度认知障碍中,依赖于舌头涂层的上角重塑

Juan-Juan Lu¹, Jie Ma², Jia-Jia Wu²

¹School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Brain research bulletin

|June 6, 2024

概括

患有无记忆性轻度认知障碍 (aMCI) 个体的舌头厚层与较差的认知功能有关,包括记忆和信息处理速度. 这种认知能力下降可能源于上 (STS) 区域功能连接性减少.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
医疗成像医学成像

背景情况:

舌头涂层对认知的影响,特别是在早期认知衰退的阶段,如记忆力缓和认知障碍 (aMCI),是公认的.
早期的aMCI涉及上突 (STS) 的功能和结构变化.
在aMCI中,不同的舌头涂层特征,特定的认知缺陷和STS重塑机制之间的关系仍然不清楚.

研究的目的:

研究不同舌头涂层类型与aMCI患者的认知表现之间的相关性.
探索与舌头涂层相关的aMCI上突 (STS) 重塑的潜在机制.
为了比较aMCI患者之间的神经成像和认知测量,薄与厚的舌头涂层.

主要方法:

采用病例控制研究设计,将aMCI患者分为薄 (n=18) 和厚 (n=21) 舌头涂层组.
参与者接受了全面的神经心理评估和多式磁共振成像 (MRI).
组对比集中在临床评估和神经影像上角 (bankssts) 的银行,利用通用线性模型将神经影像数据与认知得分联系起来.

主要成果:

与薄膜患者 (P <0.05) 相比,具有厚厚的舌头涂层的aMCI患者的立即/延迟回忆和信息处理速度 (IPS) 显著降低,信息处理速度 (IPS) 较慢.
在厚涂层组中观察到双边边缘和前双层皮层之间的功能连接 (FC) 减少 (P <0.05,AlphaSim校正).
发现了双边边缘与前面对面皮层的认知功能 (回忆,IPS) 和FC (P <0.05,邦费罗尼校正),以及群组和右边边区域同质性的相互作用效应 (ReHo) 在即时回忆 (P <0.05,邦费罗尼校正) 之间存在显著的相关性.

结论:

在aMCI患者中,厚厚的舌头涂层与较差的认知表现有关.
源自上角 (bankssts) 边缘的功能连接性下降可能是MCI患者舌头厚层所观察到的认知缺陷的基础.
这些发现增强了对舌头涂层状况如何通过在aMCI中STS区域的大脑重组来影响认知功能的理解.

关键词:

阿姆尼斯蒂克轻度认知障碍认知功能认知功能多模态核磁共振 (MRI) 是一种多模态核磁共振.上神经 (superior temporal sulcus) 是上神经的一个部分.舌头涂层是指舌头上的涂层.

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