抗力运动和乳清蛋白补充剂对老年男性认知功能的影响:一项随机,双盲,安慰剂对照试验的二次分析
Corbin Griffen1, Tom Cullen2, John Hattersley3
1Centre for Health and Life Sciences, Coventry University, Coventry CV1 2DS, United Kingdom; Human Metabolism Research Unit, University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, United Kingdom.
Experimental gerontology
|June 6, 2024
概括
乳清蛋白补充剂改善了老年男性的认知功能,特别是执行功能. 抵抗运动并没有提高认知能力,但减少了炎症标志物,没有观察到联合益处.
科学领域:
- 老年学和认知神经科学
- 运动生理学和营养
背景情况:
- 老龄化与认知能力下降有关,需要进行干预来保持大脑健康.
- 抵抗运动 (RE) 和乳清蛋白 (PRO) 是对抗与年龄相关的认知障碍的潜在策略.
研究的目的:
- 研究RE和PRO对老年男性认知功能的影响.
- 检查这些干预措施的个别和综合影响.
主要方法:
- 36名老年男性 (平均年龄67岁) 被随机分为四组:RE + PRO,RE + 控制,没有运动 (NE) + PRO,NE + 控制.
- 干预持续了12周,涉及每周两次和每天两次抵抗运动,乳清蛋白分离物或马尔托德克斯补充剂.
- 使用CANTAB电池评估认知功能,并测量生物标志物,皮质醇和胰岛素敏感性.
主要成果:
- 与对照组相比,乳清蛋白补充剂显著改善了执行功能z分数.
- 通过PRO.观察到改善全球认知功能的趋势.
- 抵抗运动减少了炎症标志物 (TNF-alpha,IL-6),但没有改善认知功能领域.
- 基线的肌肉强度和身体功能与认知功能相关,骨肌肉变化与干预后的情节性记忆相关.
结论:
- 乳清蛋白补充剂可以提高老年男性的认知功能,特别是执行功能.
- 抵抗运动有效地减少了全身炎症,但不会直接改善这一群体的认知功能.
- 在结合抵抗运动和乳清蛋白补充剂时,没有发现协同的认知益处.
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