我们如何定义4-18岁儿童的耐治疗性便秘? 一个系统的审查与元叙事合成
Vassiliki Sinopoulou1, Morris Gordon2, Shaman Rajindrajith3
1University of Central Lancashire, Preston, UK.
BMJ paediatrics open
|June 6, 2024
概括
儿科治疗耐药性便秘在研究中缺乏明确的定义,导致不一致的研究和潜在的危害. 需要达成共识的定义,以便在儿童中进行一致的诊断和治疗.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床研究方法论 临床研究方法论
背景情况:
- 治疗耐药性便秘在儿童中表现为持续的症状,尽管治疗.
- 缺乏明确的定义阻碍了适当的诊断和治疗途径.
研究的目的:
- 在儿科干预研究中系统地审查治疗耐药便秘的定义.
- 确定这种情况如何定义的变化和共同点.
主要方法:
- 系统审查CENTRAL,MEDLINE,Embase,世卫组织ICTR和临床试验.gov.gov. 的系统审查.
- 分析治疗耐药性便秘的定义的元叙事方法.
- 提取了关于定义标准,持续时间和先前治疗的数据.
主要成果:
- 包括47项研究,揭示了至少七种不同定义的儿科治疗耐药性便秘.
- "难治"和"耐火"等术语是常见的,但只有14项研究提供了明确的定义.
- 诊断标准和持续时间差异很大,一些研究缺乏明确的定义.
结论:
- 目前的儿科文献缺乏对耐治疗便秘的标准化定义.
- 达成共识的定义对于研究的一致性和防止不必要的侵入性程序至关重要.
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