快速眼动依赖与阻塞性睡眠呼吸暂停综合征的炎症活动增加有关
Asli Akyol Gurses1, Utku Ogan Akyildiz2
1Division of Clinical Neurophysiology, Department of Neurology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Brain and behavior
|June 6, 2024
概括
患有REM依赖性阻塞性睡眠呼吸暂停综合征 (OSAS) 的患者表现出炎症标志物增加,特别是血小板分布宽度 (PDW) 和全身免疫炎症指数 (SII). 这表明需要仔细监测这种OSAS亚型中相关的炎症后果.
科学领域:
- 睡眠医学 睡眠医学
- 心血管健康 心血管健康
- 炎症研究 炎症研究
背景情况:
- 依赖快速眼动 (REM) 的阻塞性睡眠呼吸暂停综合征 (OSAS) 是一个通常被认为较温和的亚型.
- 然而,最近的数据将其与心脏代谢和血管问题联系起来.
- 需要进一步调查REM依赖OSAS的炎症状态.
研究的目的:
- 通过使用血小板分布宽度 (PDW) 和全身免疫炎症指数 (SII) 来评估REM依赖OSAS的炎症状态.
- 为了确定这种炎症状态是否在REM依赖性OSAS的不同定义中是一致的.
- 探索REM依赖性OSAS和炎症之间的关系.
主要方法:
- 对35名REM依赖的OSAS,35名REM独立的OSAS和25名非OSA对照患者的回顾性分析.
- 在不同组之间比较基线特征,多睡眠学,PDW和SII.
- 统计分析包括双变数和多变数回归,以BMI和心血管风险因素进行调整.
主要成果:
- 与非OSA对照组相比,REM依赖的OSAS患者的平均PDW和SII显著增加 (p=.022和p=.029).
- 在调整了BMI和心血管风险因素后,这些发现仍然很重要.
- 在REM独立的OSAS和非OSA对照之间,或在两个OSAS亚型之间没有发现显著差异.
结论:
- 依赖REM的OSAS患者表现出对炎症的敏感性增加.
- 升高的PDW和SII表明这种OSAS亚型的炎症状态.
- 这项研究是首次报告REM依赖的OSAS中的PDW和SII水平,突出显示了监测的必要性.
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