捐赠人母乳与低风险婴儿配方婴儿奶粉:一个系统性审查
Thomas McClintock1, Catherine Fiddes2,3, Shalee Harris1
1Liggins Institute, University of Auckland, Auckland, New Zealand.
Pediatric research
|June 6, 2024
概括
用捐赠人母乳补充母乳对早产婴儿纯母乳养率产生不明确的影响. 需要更多高质量的研究来确定与婴儿配方奶粉相比的好处和风险.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 哺乳期研究 哺乳期研究
背景情况:
- 在健康的婴儿中,越来越多地使用捐赠人乳 (DHM).
- 需要比较DHM补充剂与婴儿配方 (IF) 在中度晚期早产 (MLP) 和早产 (ET) 婴儿.
研究的目的:
- 研究母乳补充DHM与IF在MLP和ET婴儿中的益处和风险.
- 评估对纯母乳养 (EBF) 和其他健康结果的影响.
主要方法:
- 系统地搜索多个数据库和临床试验注册表的文献,直到2023年9月.
- 包括11项研究 (10,147名婴儿) 和6项正在进行的试验.
- 使用GRADE评估证据确定性,使用RoB1和EPHPP评估偏差风险.
主要成果:
- 研究质量低,证据确定性非常低.
- 在一些研究中,有限的证据表明DHM对EBF在出院时比IF有潜在的益处,但没有发现一致的差异.
- 没有明显影响EBF持续时间,整体母乳养,低血糖或发病率;没有报告的健康风险.
结论:
- 用捐赠人母乳补充母乳与婴儿配方奶粉对纯母乳养和健康结果的影响仍然不清楚.
- 研究质量低,结果异质,地理局限性阻碍了最终的结论.
- 高质量的研究对于在这个脆弱的婴儿群体中确定DHM补充剂的安全性和有效性至关重要.
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