在Helicobacter pylori根除治疗后长期内镜胃粘膜变化长达20年
Eri Iwata1, Mitsushige Sugimoto2,3, Yoshika Akimoto1
1Department of Gastroenterological Endoscopy, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
根除Helicobacter pylori显著降低了长期胃癌风险因素,如缩和发红. 这一改进突出了根除的突出原因.
科学领域:
- 胃肠道学和瘤学
- 微生物组和癌症研究研究
背景情况:
- 众所周知,杆菌根除可以减少胃癌的发生率.
- 根除对内镜风险因素 (如缩和肠道转化等) 的长期影响尚不清楚.
- 胃癌预防策略需要了解H.pylori治疗的持续影响.
研究的目的:
- 调查H. pylori根除后胃癌的内镜风险因素的长期变化 (长达20年).
- 评估根除对胃炎严重程度的影响,使用京都胃炎分类.
- 为了比较根除患者,从未感染过的个体和目前感染的个体之间的内镜发现.
主要方法:
- 根据"京都分类"对167名患者的内镜性胃炎严重程度的回顾性评估.
- 根除后的平均随访期为15.7年.
- 胃癌风险得分的比较,随着时间的推移,缩小,扩散红色和地图般的红色.
主要成果:
- 在根除组中,胃癌总风险评分,缩和扩散红色的长期显著改善 (p < 0.001).
- 在从未感染和当前感染组中没有观察到风险因素的显著变化.
- 随着时间的推移,在根除组 (3.6%至18.7%,p = 0.03) 观察到地图状红色的频率增加.
结论:
- 长期的H. pylori根除导致胃癌风险因素的显著内镜改善,特别是缩.
- 根除疗法是胃癌长期预防的关键组成部分.
- 基于根除前内镜性胃炎严重程度的个性化监测策略对于高危人群至关重要.
更多相关视频
05:23Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
03:47Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
相关概念视频
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
