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不同的与年龄相关的和与代谢相关的肠道微生物群特征调节心血管疾病风险
Tiange Wang1,2, Zhun Shi3,4, Huahui Ren3,4
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nature medicine
|June 6, 2024
概括
肠道微生物年龄 (MA) 影响有代谢问题的老年人心血管疾病 (CVD) 风险. 一个年轻的MA可能会抵消代谢功能障碍,促进更健康的寿命.
科学领域:
- 微生物组研究的研究.
- 代谢健康 代谢健康
- 衰老和寿命的延长
背景情况:
- 肠道微生物组的组成与新陈代谢和衰老有关.
- 代谢多病症集群 (MCs) 代表了不同的代谢亚表型.
- 了解这些关联是促进健康长寿的关键.
研究的目的:
- 研究肠道微生物组成,代谢健康和心血管疾病 (CVD) 风险之间的关系.
- 开发和验证肠道微生物年龄 (MA) 度量.
- 探索MA在调节代谢功能障碍的老年人心血管疾病风险中的作用.
主要方法:
- 根据21个代谢参数,将10207个个体分为五个代谢多病症集群 (MCs).
- 分析了4491个便甲基因组,以评估肠道微生物的组成.
- 开发并验证了一种肠道微生物年龄 (MA) 度量,在多个队列中使用55种特定年龄的微生物物种.
主要成果:
- 代谢不健康的集群 (MC4,MC5) 与代谢健康的集群 (MC1) 相比,显示心血管疾病风险显著增加.
- 肠道微生物组成与MC和时间年龄有关.
- 在老年人 (≥60岁) 中,高MA在代谢不健康的个体中加剧了心血管疾病风险,而低MA则独立于其他因素而减少了风险.
结论:
- 肠道微生物年龄 (MA) 是心血管健康的一个重要因素,特别是在代谢功能障碍的老年人中.
- 较年轻的MA可能会对与代谢多病症相关的心血管疾病 (CVD) 风险产生保护作用.
- 准肠道微生物群可能是促进健康长寿和预防心血管疾病的新策略.
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