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根据POSEIDON分类,对于预后较低的患者,不成熟卵细胞的最佳ICSI时间是最佳的

Cheng Shi¹, Ping Wang¹, Rong Liang¹

¹Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University People's Hospital, Peking University, Beijing, 100044, China.

BMC pregnancy and childbirth

|June 6, 2024

概括

在第一个极体挤出 (P-ICSI) 后4-6小时内进行细胞内精子注射 (ICSI) 是利用不成熟卵细胞在预后不佳的患者中最有效的. 这种时间改善了POSEIDON患者的胚胎利用和活产结果.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
在体外受精 (IVF)

背景情况:

在POSEIDON患者中,对未成熟卵细胞进行细胞内精子注射 (ICSI) 的最佳时间仍未确定.
这会影响早期胚胎发育和成功的怀孕结果.
波赛顿分类识别了预期IVF结果较低的患者.

研究的目的:

确定在POSEIDON患者体外成熟的生殖囊泡 (GV) 和I (MI) 基相卵细胞上进行ICSI的最合适时间.
优化这个患者群体的早期胚胎发育和活产率.

主要方法:

一项前性研究,涉及163名POSEIDON患者的239个未成熟卵细胞.
ICSI在三个不同的时间进行:P-ICSI (PB1挤出后4-6小时),R-ICSI (PB1挤出后<4小时),和E-ICSI (提取后的第二天).
收集了关于受精,胚胎发育和卵细胞线粒体分布的数据.

主要成果:

与E-ICSI (OR=3.71,P=0.061) 相比,P-ICSI组显示出更高的胚胎细胞形成趋势.
胚胎利用率在P-ICSI (OR=5.67,P<0.001) 和R-ICSI (OR=3.23,P=0.017) 组相比E-ICSI.组显著更高.
P-ICSI组的活产数最多 (5),其次是R-ICSI (1) 和E-ICSI (0);植入率也在P-ICSI (35.3%) 中最高.

结论:

在第一个极体挤出后4-6小时进行ICSI (P-ICSI) 是利用不成熟卵子细胞在预后较低的POSEIDON患者中最有效的方法.
P-ICSI显示出优越的胚胎利用率和活产结果.
线粒体分布模式在P-ICSI和R-ICSI组之间有所不同.

关键词:

在GEEEE中,GEEEE是指GEEEE.国际刑事调查局的时间表.不成熟的卵子细胞.线粒体的分布线粒体的分布在POSEIDON患者身上.

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