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儿童严重喘:喘控制得分,FeNO,螺旋计和冲动振荡计之间的关系
Gabriela Peláez1,2, Verónica Giubergia3, Belén Lucero3
1Pulmonology Department, Hospital de Pediatria Dr. Juan P. Garrahan, Combate de los Pozos 1881 (1245), Buenos Aires, Argentina. pelaezgabyeugenia@gmail.com.
BMC pulmonary medicine
|June 6, 2024
概括
严重喘的临床评分与呼吸道炎症相关,症状控制与儿童较低的FeNO水平保持一致. 这表明临床评估可以反映潜在的炎症.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 喘的临床评估通常依赖于可能不准确反映呼吸道炎症的参数.
- 评估呼吸道炎症对于治疗儿童严重喘至关重要.
研究的目的:
- 调查严重喘儿童的临床评分 (CS) 与呼吸道炎症的客观测量 (精神测量,脉冲振荡测量,FeNO) 之间的相关性.
主要方法:
- 一项多中心,前性,横截面研究,涉及81名严重喘儿童 (6-18岁).
- 收集的数据包括临床得分,螺旋计 (S),脉冲振荡计 (IO) 和分数呼出的氧化 (FeNO).
- 使用喘控制测试 (ACT) 和GINA问卷 (GINAq) 来评估喘控制.
主要成果:
- 在49%的患者中观察到FeNO水平≥25ppb (表明呼吸道炎症).
- FeNO与ACT (ROC AUC 0.71) 和GINAq (ROC AUC 0.69) 均显示出中等相关性.
- 对于两个临床评分,确定了FeNO>39ppb的Youden切断值.
结论:
- 根据ACT和GINAq的测量,严重喘儿童的临床症状控制与较低的FeNO水平相关.
- 临床评分显示,在这个儿科群体中,呼吸道炎症的客观标志物与临床评分有很好的相关性.
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