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编程死亡-ligand 1表达在未知初级癌症的癌症

Hye Min Kim¹, Ja Seung Koo²

¹Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.

|June 6, 2024

概括

在未知初级癌症 (CUP) 中,编程死亡配体1 (PD-L1) 表达显著变化,这取决于所使用的抗体和评分方法. 在这项研究中,PD-L1阳性率与组织学或临床亚型没有差异.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

不知原发性癌 (CUP) 是一个诊断挑战.
编程死亡连接体1 (PD-L1) 是各种癌症中重要的免疫检查点目标.

研究的目的:

通过使用多种抗体和评分系统,研究CUP中PD-L1的表达.
确定PD-L1表达和CUP中的临床病理参数之间的关联.

主要方法:

来自72例CUP病例的组织微阵列使用免疫组织化学分析PD-L1与克隆22C3,SP142,SP263和28-8.
进行了CK7和CK20染色,以帮助分型.
应用了各种各样的评分指标,包括瘤比例得分 (TPS),免疫细胞 (IC) 得分和综合阳性得分 (CPS).

主要成果:

根据抗体和评分方法,PD-L1阳性率从5.6%到48.6%不等.
PD-L1 SP142 TC和PD-L1 SP263 IC分别显示了最低和最高的阳性率.
不同组织学亚型,临床亚型或CK7/CK20状态之间没有观察到PD-L1阳性的显著差异.

结论:

在CUP中PD-L1表达是高度可变的,并且取决于所选择的抗体和评分系统.
目前的PD-L1测定显示出相当好的协议,但标准化对于CUP的临床应用至关重要.
PD-L1表达水平似乎与CUP中的标准临床病理特征无关.

关键词:

癌瘤的癌症是什么在PD-L1中.主要已知的主要已知.

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