乳酸脱酶与呼吸机相关的肺炎风险之间的关联:对2001-2019年MIMIC数据库的分析
Xiangfeng Qian1, Yi Sheng1, Yinsheng Jiang1
1Department of Emergency Medicine, Linping Campus, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311100, P.R. China.
血清中乳酸脱酶 (LDH) 水平升高与呼吸机相关肺炎 (VAP) 的风险增加以及ICU患者机械呼吸持续时间的延长有关. 较高的LDH可能有助于监测VAP风险.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 血清乳酸脱酶 (LDH) 是一种非特异性炎症标记物.
- 以前的报道表明,LDH与肺炎预后有关.
研究的目的:
- 评估血清LDH水平与呼吸机相关肺炎 (VAP) 风险之间的关系.
- 评估LDH水平与重症监护室 (ICU) 患者机械通风持续时间的相关性.
主要方法:
- 使用密集护理的多参数智能监测数据库 (2001-2019) 进行的回顾性队列研究.
- 包括年龄在18岁以上的ICU患者,接受机械呼吸.
- 分析了LDH水平 (连续和分类) 使用逻辑和线性回归,并限制立方线曲线.
主要成果:
- 在9164名患者中,有646名患者发展为VAP (7.05%).
- 较高的LDH水平显著增加了VAP风险 (OR=1.15) 并与机械通风持续时间 (β=4.49) 呈正相关.
- 与210 IU/L以下患者相比,LDH水平为279-390 IU/L和390 IU/L以上的患者表现出更高的VAP风险和更长的通风持续时间.
结论:
- 血清LDH水平升高与VAP风险增加有关.
- 较高的LDH水平与更长时间的机械通风相关.
- 血清LDH可以作为监测ICU患者VAP风险的有用生物标志物.
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