C-反应蛋白是主要脑内出血患者下肢深静脉血栓的预测因子
Gang Wang1,2,3,4, Bao-Fang Wu1,2, Wen-Jun Zhao5
1Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
European journal of medical research
|June 6, 2024
概括
在初级脑内出血 (ICH) 患者中,C-反应蛋白 (CRP) 水平升高显著增加了下肢深静脉血栓症 (LEDVT) 的风险. 早期识别高CRP可以帮助管理LEDVT风险.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 炎症研究 炎症研究
背景情况:
- 系统性炎症越来越多地被认为是各种疾病的一个因素.
- 下肢深静脉栓塞 (LEDVT) 是急性神经事件后的一个常见并发症.
- 在脑内出血 (ICH) 患者中,炎症标志物和LEDVT风险之间的关系需要进一步阐明.
研究的目的:
- 调查血清C反应蛋白 (CRP) 水平与患LEDVT的风险之间的关联.
- 为了确定是否升高的CRP可以作为LEDVT在初级ICH患者的预测标记.
主要方法:
- 对538名初级ICH患者进行了回顾性观察性研究.
- 使用了倾向得分匹配 (PSM) 和后勤回归模型.
- 分析的重点是LEDVT发生在ICH发病后14天内以及入院时的CRP水平.
主要成果:
- 患有较高CRP (≥1.59毫克/升) 的患者的LEDVT发病率明显较高 (24.6%对比4.1%,P<0.001).
- 在调整后的分析中,较高的CRP水平与LEDVT风险增加10.8倍相关 (95%CI为4.5-25.8,P<0.001).
- 在CRP水平和LEDVT风险之间观察到显著的非线性关联.
结论:
- 升高的初始CRP水平是LEDVT在初级ICH患者的显著独立预测因素.
- CRP可以帮助识别患有LEDVT高风险的患者,促使早期干预.
- 建议对高CRP进行临床警,以便在ICH幸存者中及时进行LEDVT治疗.
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