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通过AAV9疗法调节TAU可增强青光眼中Akt/Erk生存信号,减轻视网膜退行性表型

Kanishka Pushpitha Maha Thananthirige1, Nitin Chitranshi2, Devaraj Basavarajappa2

  • 1Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Sydney, NSW, 2109, Australia. kanishkapushpitha.mahathananthirige@mq.edu.au.

Acta neuropathologica communications
|June 6, 2024
PubMed
概括

这项研究表明,陶蛋白对视网膜健康起着至关重要的作用. 调节陶氏度会影响视网膜神经元,而陶氏沉默可以保护人们免受青光眼引起的退化.

关键词:
眼光障碍症是什么 眼光障碍症是什么眼内压力 眼内压力这些微管是微管子.神经退行发生神经退行.眼神经的视觉神经是什么视网膜质细胞 视网膜质细胞塔乌·塔乌 (Tau Tau) 是一个

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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