急性星细胞反应与内血管治疗治疗中风后3个月的功能结果有关
Ada Boutelier1,2, Véronique Ollivier2, Mikael Mazighi2,3,4,5,6
1Cognitive Neurology Center, GHU APHP Nord, Hôpital Lariboisière-Fernand Widal, Université Paris Cité, Paris, France.
European stroke journal
|June 7, 2024
概括
在大血管封闭 (LVO) 和急性缺血性中风 (AIS) 的内血管治疗 (EVT) 之前,高YKL-40水平预示着不良结果. 用YKL-40表示的早期星细胞反应与AIS患者功能恢复的恶化有关.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 脑卒中研究 脑卒中研究
背景情况:
- 在接受内血管治疗 (EVT) 的大血管封闭 (LVO) 急性缺血性中风 (AIS) 患者中,超过50%的患者在3个月后经历严重残疾.
- 急性星细胞炎症反应在AIS后的大脑变化和功能结果中的作用尚未完全理解.
研究的目的:
- 评估YKL-40水平,YKL-40是一种由反应性星球细胞释放的糖蛋白,作为使用EVT治疗的LVO AIS患者功能性结局的潜在生物标志物.
- 调查不同时间点在血YKL-40度和EVT后功能恢复之间的关联.
主要方法:
- 一个单一的前性队列研究包括120名LVO AIS患者,他们在2016年至2020年期间接受了EVT.
- 血YKL-40水平在三个时间点测量:在EVT之前,在EVT后1小时内,在EVT后24小时内.
- 在治疗后3个月使用修改的兰金尺度 (mRS) 评估了功能性结果.
主要成果:
- 在EVT前的血YKL-40度独立地与3个月后更糟糕的功能结果相关 (调整后的cOR,1.59;p=0.027).
- 优秀的功能性结果与EVT前和后1小时内测量的较低YKL-40水平相关 (分别为p=0.005和p=0.003).
- 在EVT后24小时测量YKL-40水平并没有显示与功能结果的显著关联.
结论:
- 这项研究表明,星状细胞炎症反应,特别是在再通道化之前,与接受EVT治疗的AIS患者的功能结果较差有关.
- 早期测量YKL-40可以作为一个有价值的生物标志物来预测中风的结果,并指导个性化的患者护理.
- 这一发现突显了针对早期星球细胞反应的潜力,以改善急性缺血性中风的恢复.
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