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相关概念视频

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

418
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
418
Drug Delivery: Overview01:16

Drug Delivery: Overview

287
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
287
Routes of Drug Administration: Enteral01:18

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Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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相关实验视频

Updated: Jun 24, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
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对于食品生物活性化合物的贝基输送系统.

Xueqing Yao1, Yubo Zhu1, Huiyun Chen2

  • 1Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, China-Canada Joint Lab of Food Nutrition and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.

International journal of biological macromolecules
|June 7, 2024
PubMed
概括
此摘要是机器生成的。

贝是一种天然树脂,为开发先进的输送系统提供独特的特性. 这些基于贝的平台提高了食品生物活性化合物的稳定性和生物可用性.

关键词:
生物活性化合物 生物活性化合物交付系统的交付系统.封装封装是一种封装.贝的贝,就是贝.有针对性的释放.

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科学领域:

  • 食品科学 食品科学 食品科学
  • 材料科学 材料科学 材料科学
  • 生物技术是生物技术.

背景情况:

  • 贝是一种具有两性,pH响应,生物相容性和生物降解性质的天然树脂.
  • 越来越多的人对利用糖来控制食品生物活性化合物的输送感兴趣.
  • 基于贝的系统为改善功能性食品应用提供了潜力.

研究的目的:

  • 审查食品生物活性化合物的贝基输送系统最近的进展.
  • 研究这些系统的制备方法,形成机制,结构和交付性能.
  • 讨论当前基于贝的交付平台的缺陷和挑战.

主要方法:

  • 关于基于贝的输送系统的文献综述.
  • 对各种系统类型的分析:纳米粒子,状颗粒,水凝,纳米纤维和纳米微粒.
  • 评估准备,形成,结构和交付性能.

主要成果:

  • 基于贝的系统,包括纳米粒子和水凝,提高生物活性化合物的稳定性和保质期.
  • 这些系统使小肠或结肠的向释放成为可能.
  • 食品生物活性化合物的增强生物可用性是通过贝封装来实现的.

结论:

  • 基于贝的配送系统显示出功能性食品应用的重大前景.
  • 对克服系统缺陷的进一步研究可以导致更高效的平台.
  • 这些发现指导了先进的贝基传递技术的未来发展.