伊索托尼塔,一种来自新兴家族的合成阿片类药物:尼塔
Jean-Joseph Bendjilali-Sabiani1, Céline Eiden2, Margot Lestienne2
1Laboratoire de toxicologie, service de pharmacologie médicale et toxicologie, CHU de Montpellier, 34295 Montpellier, France.
概括
合成阿片类药物异尼 (IZN) 在法国出现,由于其高强度,造成了严重的过量使用风险. 早期警报和识别对公共卫生至关重要.
科学领域:
- 法医毒理学 法医毒理学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 自2019年以来,合成阿片类药物市场已经出现了强大的2-基胺醇 (尼塔).
- 伊索托尼塔 (IZN),一种尼塔,比吗啡和芬太尼具有显著更高的μ-阿片类受体亲和力.
- 2023年3月,IZN首次在法国南部被发现,这表明了新的公共卫生威胁.
研究的目的:
- 报告在法国使用的异尼 (IZN) 的初始识别和特征.
- 要突出与这种新型合成阿片类药物相关的过量使用风险和公共卫生影响.
主要方法:
- 追溯分析涉及法国南部涉嫌使用IZN的9起事件报告 (2023年3月至4月).
- 在产品样本和生物标本 (尿液,尸体) 中使用毒理学分析识别 IZN.
- 关于尼塔功效,纳洛反应和检测挑战的文献综述.
主要成果:
- 在9份报告中,IZN在4个案例中得到证实,在其他案例中被怀疑.
- 两例过量病例涉及样本中IZN的识别;一个需要住院治疗,另一个导致死亡.
- IZN案件涉及平均年龄为44.9岁的个人,其中一些产品非法采购.
结论:
- 异尼 (IZN) 在法国是一个严重的新兴威胁,因为它具有很高的效力和严重过量剂量的潜力.
- 迅速传播警报和加强毒理监测对于减轻与新型合成阿片类药物相关的风险至关重要.
- 对纳洛的有限反应和检测困难强调了需要专门的分析能力和公共卫生意识的需要.
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