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通过Pseudomonas otitidis介导的银纳米颗粒合成:特征,抗菌和抗菌膜潜力

Ashitha Jose¹, Sneha Asha¹, Anaswara Rani¹

¹Department of Zoology, Government College for Women, Thiruvananthapuram 695014, Kerala, India.

Letters in applied microbiology

|June 7, 2024

概括

由土壤细菌合成的环保银纳米颗粒 (AgNPs) 显示出适度的抗菌活性和对致病细菌的显著生物膜破坏,为生物医学应用提供了潜力.

科学领域:

纳米技术纳米技术
微生物学微生物学
生物医学科学生物医学科学

背景情况:

由于抗生素耐药性增加,对新型抗菌剂的需求正在增长.
纳米颗粒的生物合成为化学合成方法提供了一个可持续和环保的替代方案.
土壤细菌,如Pseudomonas otitidis,是纳米颗粒微生物合成的潜在候选者.

研究的目的:

探索使用土壤细菌Pseudomonas otitidis的银纳米颗粒 (AgNPs) 的环保合成.
描述合成的AgNP并评估它们对病原细菌的抗微生物活性.
为了研究生物合成的AgNP的抗菌膜潜力.

主要方法:

使用Pseudomonas otitidis和银酸盐进行AgNP的生物合成.
使用UV-Vis光谱,FTIR,SEM和XRD进行AgNP的表征.
抗菌活性测试 (光盘扩散,MIC,MBC) 和抗菌膜测试 (水晶紫,光显微镜).

主要成果:

鉴定证实了用蛋白质封闭剂形成晶体球形AgNP (平均尺寸为82.76nm).
生物合成的AgNP表现出适度的抗菌活性,对抗氏阴性和氏阳性病原体.
AgNPs显著破坏了Pseudomonas aeruginosa的生物膜.

结论:

Pseudomonas otitidis 是AgNPs的绿色合成的一个可行的代理.
生物合成的AgNP显示出作为抗菌剂和抗菌膜剂的潜力.
微生物合成的纳米粒子在生物医学应用中为对抗病原细菌提供了一个有希望的途径.

关键词:

伪omonas aeruginosa 这种类型的病毒.伪omonas otitidis 这种类型的.它是一种抗菌药物,具有抗菌作用.抗菌膜活动的抗菌膜活性.微生物合成的微生物合成银纳米颗粒的使用方法

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