大型金属-宏循环的非对称状联体:定向自我排序的选择性
Ondřej Jurček1,2,3, Subhasis Chattopadhyay2,3, Elina Kalenius4
1Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého 1946/1, CZ-61200, Brno, Czechia.
Angewandte Chemie (International ed. in English)
|June 7, 2024
概括
奇拉胆汁酸连接物产生各种各样的超分子复合体. 与可预测的结构不同的是,陈二氧化醇酸 (CDCA) 连接体产生多达120个奇拉中心的金属超分子组合的混合物.
科学领域:
- 金属至高分子化学
- 螺旋连接体设计 螺旋连接体设计
- 超分子组合 (Supramolecular Assembly) 是一个超分子组合.
背景情况:
- 大自然利用性构建块来构建复杂的结构.
- 大多数金属超分子化学都依赖于对称的,状的连接体.
- 胆汁酸提供了一个独特的性支架,用于连接体的发展.
研究的目的:
- 探索表皮性胆汁酸连接体对金属超分子组件的影响.
- 为了合成和描述新型的复合物,使用氧化醇酸 (CDCA) 衍生连接物.
- 研究由非对称联结体形成的协调产品的结构多样性和复杂性.
主要方法:
- 从陈氧胆酸 (CDCA) 中合成有机双二基连接物.
- 与二酸盐 (PdNO3) 2 的协调.
- 使用离子移动性质谱法 (IM-MS) 和密度函数理论 (DFT) 计算的结构特征.
主要成果:
- Ursodeoxycholic 酸 (UDCA) 连接体产生了一个单一的 Pd3L6 复合体.
- CDCA 配体产生了复合物的混合物 (PdnL2n,n=2-6).
- Pd6L12复合体包含120个性中心;IM-MS分离了四个不同的Pd离子.
结论:
- 连接体的表皮性,灵活性和体积显著影响了超分子组装结果.
- 不对称的性联结体使复杂的,多样化的金属上分子结构的形成.
- 先进的分析技术对于描述复杂的性协调复合体至关重要.
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