在晚期结直肠癌患者中,焦虑,抑郁和症状负担之间的关联:一个多中心横截面研究
Lili Song1, Zhongge Su1, Yi He1
1Department of Psycho-Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China.
Cancer medicine
|June 7, 2024
概括
焦虑和抑郁症显著增加了晚期结直肠癌 (CRC) 患者的症状负担. 解决这些心理症状对于全面的癌症护理和改善患者结果至关重要.
科学领域:
- 在瘤学瘤学.
- 心理瘤学 心理瘤学
- 临床研究 临床研究
背景情况:
- 晚期结肠直肠癌 (CRC) 提出了重大挑战,通常涉及同时出现的身体和心理症状.
- 症状负担显著影响了晚期CRC患者的生活质量.
研究的目的:
- 为了研究焦虑,抑郁和晚期结直肠癌患者的整体症状负担之间的关系.
- 量化心理痛苦对身体症状体验的影响.
主要方法:
- 这是一项多中心的横截面研究,涉及中国10个不同癌症中心的454名晚期CRC患者.
- 利用医院焦虑和抑郁量表和MD安德森症状清单来评估心理状态和症状负担.
- 使用多重回归分析来确定焦虑,抑郁和症状负担之间的关联.
主要成果:
- 大约三分之一的晚期CRC患者表现出焦虑或抑郁的症状.
- 与没有焦虑或抑郁症的患者相比,焦虑或抑郁症患者报告的症状负担显著增加,症状中度至严重的患者数量更多 (p < 0.001).
- 焦虑 (β=15.33,p<0.001) 和抑郁 (β=13.63,p<0.001),以及疾病阶段 (β=-2.55,p=0.003),独立地与增加的症状负担有关.
结论:
- 焦虑和抑郁与晚期癌症患者的症状负担更高显著相关.
- 这些发现强调了瘤专业人员需要在先进的癌症护理中主动选和管理心理痛苦的必要性.
- 将心理支持纳入症状管理计划对于改善患者福祉至关重要.
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