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创伤性脑损伤后加速衰老:一个ENIGMA多队列大分析

Emily L Dennis^1,2, Samantha Vervoordt³, Maheen M Adamson^4,5

¹Department of Neurology, University of Utah, Salt Lake City, UT, USA.

Annals of neurology

|June 7, 2024

概括

随着时间的推移,复杂的轻度,中度和重度创伤性脑损伤 (cmsTBI) 恶化后,大脑结构发生变化,特别是在男性中. 这种预测的年龄差异 (PAD) 在受伤数十年后进展,但与认知表现无关.

科学领域:

神经成像是一种神经成像.
创伤性脑损伤研究研究
老龄化和大脑健康问题

背景情况:

创伤性脑损伤 (TBI) 后的长期结构性大脑变化尚未完全理解.
使用MRI估计大脑年龄为量化这些长期影响提供了一个潜在的方法.
以前的研究表明,复杂的轻度,中度和重度TBI (cmsTBI) 与预测年龄差异 (PAD) 的增加有关.

研究的目的:

调查cmsTBI患者的伤害 (TSI) 后的时间是否会增加PAD.
为了确定伤害严重程度和性别是否会影响PAD随时间的进展.
探索PAD和TBI后的认知表现之间的关系.

主要方法:

使用了来自ENIGMA AMS-TBI工作组的大型TBI样本 (n=343) 和对照 (n=540).
在7个队伍中汇总的T1w-MRI横截面数据.
使用类似于之前的TBI研究的预测建模算法计算大脑年龄.

主要成果:

发现PAD随着STI的增加而扩大.
与女性相比,男性的大脑年龄更为先进.
在PAD和认知表现之间没有发现显著的关联.

结论:

在cmsTBI之后的大脑结构的变化是动态的,并在几十年内演变.
一个初始的变化时期之后是相对稳定的,然后是大脑形态学的进一步变化.
这些发现凸显了TBI后结构性大脑变化的渐进性质.

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Traumatic Brain Injury l: Introduction

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