评估法维皮拉维尔与放射性对比剂之间的潜在相互作用
Sonay Aydin1, Ozlem Celik Aydin2, Mesut Furkan Yazar3
1Department of Radiology, Erzincan Binali Yıldırım University, Faculty of Medicine, Erzincan 24100, Türkiye. sonaydin89@hotmail.com.
World journal of radiology
|June 7, 2024
概括
这项研究发现,服用法维皮拉维尔 (一种COVID-19药物) 和放射性对比剂的老年患者经历了轻微的药物相互作用,包括肌素升高和恶心. 年龄是这些相互作用的重要风险因素.
科学领域:
- 药理学 药理学是指药理学的学科.
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 费维皮拉维尔是2019年冠状病毒病 (COVID-19) 的常见治疗方法.
- 与法维皮拉维尔的药物相互作用得到了充分研究,但与放射性对比剂的相互作用没有.
- 放射性对比剂对于诊断成像至关重要.
研究的目的:
- 为了研究法维皮拉维尔和放射性对比剂之间的潜在药物相互作用.
主要方法:
- 对接受法维皮拉维尔治疗COVID-19的1046名患者的回顾性分析.
- 在法维皮拉维尔治疗期间,患者接受了对比度增强的CT或MRI扫描.
- 从计算机化患者档案和药监表格中评估的数据.
主要成果:
- 4%的患者 (42例) 显示可能的药物相互作用.
- 增加年龄与更高的药物相互作用风险显著相关 (每年增加1.63倍).
- 性别之间没有发现相互作用发生的显著差异.
结论:
- 联合使用法维皮拉维尔和对比剂可能会导致肌素和透氨酶水平的增加,以及更多的恶心/吐.
- 大多数发现的药物相互作用在临床上都是温和的.
- 药物相互作用的频率随着年龄的增长而增加.
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