对急性过敏反应的治疗偏好:一个离散选择实验
Sofia Löfvendahl1, Emelie Andersson2, Sara Olofsson2
11The Swedish Institute for Health Economics, Lund, Sweden.
Journal of health economics and outcomes research
|June 7, 2024
概括
患者更喜欢新的口服皮质类固醇薄膜,而不是急性过敏反应 (AAR) 的药片,显示出大量愿意支付更快的症状缓解和更容易的管理. 这表明口腔电影格式的经济效益很大.
科学领域:
- 药理学 药理学是指药理学的学科.
- 卫生经济学 卫生经济学
- 患者报告的结果
背景情况:
- 急性过敏反应 (AARs) 需要及时接受皮质类固醇治疗以减轻严重程度.
- 在水中溶解的传统皮质类固醇片是一种常见的治疗方法,但可能很麻烦.
- 一种新的口服薄膜配方提供了一个潜在的更快,更方便的替代方案,用于在AAR中输送皮质类固醇.
研究的目的:
- 在AAR中评估患者对皮质类固醇施用方式的偏好.
- 评估为皮质类固醇治疗的特定属性支付意愿 (WTP).
- 为了比较患者对新口膜和传统药片的偏好.
主要方法:
- 一个基于网络的离散选择实验 (DCE) 调查对瑞典成年人进行了管理,他们之前曾使用过针对AARs的皮质类固醇.
- DCE评估了WTP的给药方式 (口服膜与药片),症状缓解的时间和价格.
- 使用后勤回归分析,从强制选择 (FC) 和非强制选择 (UC) 模型中推导出WTP值.
主要成果:
- 所有DCE属性都显著预测了治疗选择 (p<.001).
- 口服膜与片剂的增量WTP为409瑞典克朗 (FC型) 和574瑞典克朗 (UC型),当考虑当前治疗价值时,降至336瑞典克朗.
- 较短的症状缓解时间减少了每分钟17瑞典克朗的WTP;在患有循环症状或吞困难的患者中观察到口服膜的WTP更高.
结论:
- 皮质类固醇的口服薄膜配方在瑞典为患有AAR的患者提供了与药片相比的实质性经济效益.
- 患者的偏好强烈支持口腔膜提供的方便性和潜在的症状缓解速度.
- 这些发现支持采用口服膜作为在管理AAR中偏好使用皮质类固醇的首选给药方式,特别是在特定的患者亚组中.
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