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Xiangui Zhang¹, Rui Feng², Yaqian Xu¹

¹Breast Center, Peking University People's Hospital, Beijing, China.

|June 7, 2024

概括

在治疗前检测到的基线循环瘤DNA (ctDNA) 可以预测乳腺癌早期患者的预后. 诊断时的高ctDNA水平与明显较低的无复发生存率有关.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断学
基因组学就是基因组学.

背景情况:

循环瘤DNA (ctDNA) 显示出监测治疗和检测疾病复发的前景.
基线ctDNA对早期乳腺癌预后的预测价值仍然不清楚.
早期的乳腺癌诊断和预后对于有效的治疗策略至关重要.

研究的目的:

评估基线ctDNA在早期乳腺癌患者的预后预测价值.
为了确定诊断时ctDNA检测是否可以预测患者的结果.
调查基线ctDNA水平与早期乳腺癌的存活率之间的关联.

主要方法:

招募了90名乳腺癌早期患者和24名健康对照.
在任何治疗之前,在诊断时收集的外周血液样本.
利用针对性深度测序与1021个癌症基因NGS面板来检测ctDNA.

主要成果:

在67.9%的侵袭性乳腺癌患者中检测到ctDNA,但在位管道癌 (DCIS) 中没有.
在侵袭性乳腺癌患者中,高水平的ctDNA与明显较低的无复发生存率相关 (P=0.0036).
在DCIS患者中没有检测到ctDNA.

结论:

基线ctDNA可能作为早期乳腺癌的预后生物标志物.
需要进一步的大规模研究来验证这些发现.
诊断时ctDNA检测可能有助于早期乳腺癌的风险分层.

关键词:

乳腺癌的早期发展循环瘤DNA (ctDNA) 的发生.下一代测序 (NGS) 是指下一代的测序.预后预后预后

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