临床和成像特征与长期COVID患者的肺功能测试的关联
Lin-Mei Zhao1,2, Andrew C Lancaster1,3, Ritesh Patel1
1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Heliyon
|June 7, 2024
概括
后COVID肺功能下降与较高的中性粒细胞计数,较低的淋巴细胞计数以及特定的肺成像发现,如地面玻璃不透明度有关. 这些因素可能有助于预测COVID-19感染后的长期肺部问题.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 长期的COVID可能会导致持续的肺部问题.
- 识别肺功能下降的预测因素对于患者管理至关重要.
- 了解COVID后肺功能障碍的临床和成像标记是必不可少的.
研究的目的:
- 为了确定与COVID后肺功能下降相关的临床和成像特征.
- 探索影响COVID-19后长期肺功能的因素.
- 寻找COVID-19后肺功能下降的潜在指标.
主要方法:
- 从COVID-19中康复的22名患者进行了连续的肺功能测试 (PFT) 和胸部CT扫描.
- 患者被分为"下降" (>10%FEV1下降) 和"稳定" (≤10%FEV1下降或改善) 组.
- 统计分析 (曼-惠特尼U,T-测试,Chi-squared) 将临床,实验室,PFT和CT数据与不同组进行了比较.
主要成果:
- 衰退组显示出较高的中性粒细胞比例和数量,较低的淋巴细胞比例.
- 在下降组中,在诊断和随访时CT上观察到地面玻璃不透明度 (GGO) 和CT上的网状体的更高参与.
- 衰退组的ICU入院率明显高于衰退组.
结论:
- 中性粒细胞计数,淋巴细胞计数减少以及特定的CT发现 (网膜,GGO) 与COVID后的肺功能下降有关.
- 这些因素可以作为预测COVID-19后肺功能下降的指标.
- 研究结果提供了对COVID-19感染的长期后果的见解.
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