在急性损伤中,IRF8维持单核细胞和中性粒细胞功能
Na Li1,2, Stefanie Steiger3, Ming Zhong1
1Department of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, 518107, Shenzhen, China.
Heliyon
|June 7, 2024
概括
干扰素调节因子8 (IRF8) 通过调节免疫细胞来保护损伤. 缺少IRF8会通过损害树突细胞功能和增加中性粒细胞活性,使急性损伤恶化.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學.
- 分子生物学分子生物学
背景情况:
- 免疫细胞极大地影响急性损伤 (AKI) 的发生.
- 转录因子如干扰素调节因子8 (IRF8) 控制免疫细胞功能.
- IRF8主要表达在常规树突细胞1型 (cDC1s) 和单细胞中.
研究的目的:
- 研究IRF8在AKI期间免疫反应中的作用.
- 在AKI模型中确定IRF8缺乏对脏免疫细胞透和功能的影响.
主要方法:
- 在人类AKI脏活检和免疫细胞中分析IRF8表达.
- 使用小鼠模型的缺血-再输液损伤 (IRI) 诱导的AKI.
- 在野生型和缺少Irf8的小鼠中比较功能,免疫细胞透和中性粒细胞外细胞陷 (NET) 形成.
主要成果:
- 在IRI后,缺少Irf8的小鼠表现出恶化的功能障碍和管状缩.
- 全球IRF8缺乏导致cDC1受损和单细胞衍生的树突细胞 (moDC) 成熟,激活和贩运.
- 在AKI之后,在Irf8缺乏的小鼠中观察到中性粒细胞的增加和NET的形成.
结论:
- 在AKI中,IRF8起着至关重要的免疫调节作用,主要通过cDC1功能.
- 缺少IRF8会通过调节cDC1s并促进中性粒细胞活性而加剧损伤.
- IRF8成为AKI治疗的潜在治疗标.
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