水平与败血症患者28天死亡率之间的关系:使用MIMIC-IV数据库的二次数据分析
Juan Tang1,2, Peiling Zhao1, Yi Li1,2
1Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, 28, Guiyi Street, Guiyang, Guizhou, China.
Heliyon
|June 7, 2024
概括
血清水平影响败血症患者的生存率. 高和低水平都与败血症患者28天死亡风险增加有关,突出显示了关键的U形关系.
科学领域:
- 关键护理医学 关键护理医学
- 临床化学 临床化学
- 流行病学 流行病学
背景情况:
- 血清水平与败血症患者的死亡率之间的关系需要进一步调查.
- 现有关于这个主题的研究提出了相互矛盾的发现.
研究的目的:
- 检查血清水平与败血症患者28天死亡率之间的关联.
- 为了增加有关在败血症结局中的作用的证据基础.
主要方法:
- 使用密集护理IV (MIMIC-IV) 数据库的医学信息中心进行回顾性队列研究.
- 包括349,080名败血症患者.
- 在ICU入院时血清作为暴露,28天死亡率作为结果,控制混因素.
主要成果:
- 在血清和28天死亡率之间观察到U形关系.
- 转折点被确定为4.10 mmol/L.
- 在4.10mmol/L以下,较低的与较低的死亡率有关;在4.10mmol/L以上,较高的与较高的死亡率有关.
结论:
- 血清水平过高和过低都与败血症患者28天死亡风险增加有关.
- 这些发现强调了监测和管理水平在败血症管理中的重要性.
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