在经历重大腹部手术的老年患者中,术后睡眠障碍的内科用德克斯梅德托米丁:随机对照试验协议
Xiu Yang1,2, Jing-Hui Hu1,2, Li-Ping Fan3
1Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Heliyon
|June 7, 2024
概括
这项研究调查了德克斯梅德托米丁是否可以减少腹部重大手术后老年患者的手术后睡眠障碍. 结果将指导改善手术患者的睡眠质量管理.
科学领域:
- 麻醉学和外科手术期间的医学.
- 睡眠医学 睡眠医学
- 老年人手术是一门老年人手术.
背景情况:
- 在接受重大腹部手术的患者中,术后睡眠障碍 (PSD) 是常见的.
- 德克斯梅德米丁在手术环境中增强睡眠质量方面显示出有前途.
- 接受重大腹部手术的老年患者是调查睡眠障碍的关键人口.
研究的目的:
- 评估两次手术内用德克斯梅德托米丁剂量在老年患者PSD预防方面的疗效.
- 为了比较德克斯梅德托米丁与安慰剂对腹部手术后睡眠质量的影响.
- 为优化麻醉管理提供证据,以改善患者的睡眠结果.
主要方法:
- 随机,双盲,安慰剂对照试验,包括210名老年患者 (≥65岁).
- 三个手臂:0.3微克/千克/小时德克斯梅德托米丁,0.6微克/千克/小时德克斯梅德托米丁,或正常盐水安慰剂.
- 主要终点:术后一夜发生PSD (雅典失眠量表);次要终点包括疼痛,妄想,抑郁和恢复质量.
主要成果:
- 该研究目前正在招聘,尚未产生结果.
- 数据收集包括通过Xiaomi Mi Band 7收集睡眠参数.
- 分析将重点关注PSD的主要终点和各种二次临床结果.
结论:
- 该试验旨在建立改善老年手术患者手术后睡眠质量的临床证据.
- 这些发现将为有关使用德克斯梅德托米丁用于睡眠障碍管理的麻醉方案提供信息.
- 这项研究解决了在进行重大腹部手术后增强康复的重大未满足需求.
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