儿童非结核性真菌菌病:系统性审查和元分析
Xiaoyi Jiang1, Yi Xue1, Peixuan Men2
1National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
在全球范围内,儿童非结核性菌根病 (NTM) 的病例正在上升. 淋巴结是最常见的部位,Mycobacterium avium复合体是儿科病例中占主导地位的病原体.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 全球范围内,非结核性真菌菌 (NTM) 疾病的患病率在儿童中不断增加.
- 儿科NTM疾病的表现与成年人不同,但理解仍然有限.
研究的目的:
- 分析儿童群体中NTM疾病的流行率,常见的病变部位和物种分布.
- 为儿童NTM流行病学提供全面的概述.
主要方法:
- 来自英语和中文数据库的横截面和队列研究的系统审查和元分析.
- 纳入标准:使用公认的识别方法报告NTM物种组成和儿童的病变部位的研究.
- 随机效应模型用于评估患病率和病变部位;使用科克兰的Q和I2统计学分析异质性.
主要成果:
- 儿科NTM疾病的患病率在每10万人中从0.6到5.36不等,欧洲的患病率最高.
- 淋巴结是最常见的损伤部位 (71.1%),其次是肺部 (19.3%) 和皮肤/软组织 (16.6%).
- 在MAC中,Mycobacterium avium复合体 (MAC) 是最常见的NTM病原体 (54.9%),Mycobacterium avium比Mycobacterium intracellulare更为普遍.
结论:
- 淋巴结的参与在儿科NTM疾病中最常见.
- 菌是儿童中发现的主要NTM物种.
- 研究结果强调了儿科和成人患者之间NTM疾病表现的关键差异.
更多相关视频
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
相关概念视频
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
