TME风险评分:一种基于瘤微环境的模型,用于预测头部和部状细胞癌患者的预后和免疫治疗

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Yu Li^1,2,3,4,5, Xiaozhou Pan^1,2,3, Wenwei Luo⁶

¹Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.

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概括

一个新的TME风险评分有效地预测了头部和部状细胞癌 (HNSCC) 的结果. 这一基于瘤微环境 (TME) 基因的得分显示了预测患者生存率和免疫治疗反应的潜力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物信息学是一种生物信息学.

背景情况:

瘤微环境 (TME) 显著影响头部和部状细胞癌 (HNSCC) 的进展和预后.
鉴定生物标志物对于预测HNSCC治疗结果至关重要.

研究的目的:

开发和验证TME相关风险评分 (TMErisk) 以预测HNSCC的整体存活率和免疫治疗反应.
分析与HNSCC预后相关的免疫和结构特征.

主要方法:

使用ESTIMATE算法分析HNSCC中的免疫和 stromal状态.
采用差异基因表达和权重基因共同表达网络分析 (WGCNA) 来识别与TME相关的基因.
应用了Cox单变量和LASSO回归分析,以使用11个选定的基因构建TME风险得分模型.

主要成果:

开发了一种11基因的TME风险评分模型,具有显著的整体生存预测潜力.
高的TME风险得分与免疫/肌瘤得分降低,瘤纯度增加,免疫检查点表达减少和免疫细胞透率降低相关.
在HNSCC患者中,较高的TME风险得分与较差的整体存活率和免疫治疗结果有关.

结论:

TME风险评分作为一个有前途的生物标志物,用于预测HNSCC的预后和免疫治疗疗效.
这种模型为TME在HNSCC进展和治疗反应中的作用提供了有价值的见解.
需要对TME风险评分进行进一步的临床验证,以便在HNSCC患者管理中进行常规应用.

关键词:

在HNSCC中,我们可以看到HNSCC.免疫治疗是一种免疫疗法.预测预测预测预测身体突变的体质突变在TME中,它是最重要的.瘤的纯度瘤的纯度

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